Two antioxidants are better than one.

Journal article

New evidence suggests that the cellular oxygen-sensing hypoxia-inducible factor(HIF) pathway may be protected by a double buffer of cellular antioxidant defense. Key players in the oxygen-dependent regulation of this pathway are the prolyl hydroxylase domain-containing enzymes (PHDs) that catalyze the prolyl-4-hydroxylation of HIFα, dependent on the presence of oxygen, 2-oxoglutarate, and iron in the ferrous (Fe(2+)) form. Vitamin C is also required as a cofactor, possibly to maintain the catalytic iron center in its functional Fe(2+)) state, although both the mechanism and the in vivo requirement are not absolutely clear.

Authors: Lappin, T; Masson, N

• Publication status: Published
• Journal: Blood
• Volume: 117
• Issue: 20
• Pages: 5276-5277
• Publication date: 2011-05-01
• DOI: 10.1182/blood-2011-03-340414
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English