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Structural studies on foot-and-mouth disease virus

Abstract:

Foot-and-mouth disease viruses (FMDVs) constitute the aphthovirus genus of the Picornaviridae. The structures of Oi subtype viruses OiK and G67 have been solved and comparisons reveal the structural basis of monoclonal antibody escape mutations in G67. Escape mutations are seen to occur at surface-exposed residues and to provoke structural changes limited to the altered side chains. Comparisons of the structures of O1 and O1BFS (Acharya et al., Nature 337, 7...

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Institution:
University of Oxford
Department:
Life and Environmental Sciences Division

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Role:
Supervisor
Role:
Supervisor
Publication date:
1993
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603835867
URN:
uuid:438dc0ae-b899-40fd-84dc-03d3fc1a537f
Local pid:
td:603835867
Language:
English
Subjects:

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