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Regional fat depot masses are influenced by protein-coding gene variants

Abstract:

With the identification of a large number of genetic loci associated with human fat distribution and its importance for metabolic health, the question arises as to what the genetic drivers for discrete fat depot expansion might be. To date most studies have focussed on conventional anthropometric measures such as waist-to-hip ratio (WHR) adjusted for body mass index. We searched for genetic loci determining discrete fat depots mass size using an exome-wide approach in 3 large cohorts. Here we...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0217644

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0002-2422-248X
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
14
Issue:
5
Article number:
e0217644
Publication date:
2019-05-30
Acceptance date:
2019-05-15
DOI:
EISSN:
1932-6203
Source identifiers:
968927
Pubs id:
pubs:968927
UUID:
uuid:4376240f-0cb4-414e-b079-592ef6ad97b2
Local pid:
pubs:968927
Deposit date:
2019-06-24

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