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Pharmacokinetics of piperaquine and safety profile of dihydroartemisinin-piperaquine co-administered with antiretroviral therapy in malaria-uninfected HIV-positive Malawian adults

Abstract:

There are limited data on the pharmacokinetic and safety profiles of dihydroartemisinin-piperaquine (DHA-PQ) among human immunodeficiency virus infected (HIV+) individuals taking antiretroviral therapy (ART). In a two step (parallel-group) pharmacokinetic trial with intensive blood sampling, we compared area under the concentration-time curve (AUC0-28 days) and safety outcomes of piperaquine among malaria-uninfected HIV+ adults. In step 1, half the adult dose of DHA-PQ was administered for th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.00634-18

Authors


Dzinjalamala, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Mallewa, J More by this author
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European and Developing Countries Clinical Trials Partnership More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
8
Pages:
e00634-18
Publication date:
2018-05-21
Acceptance date:
2018-05-15
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:854347
URN:
uri:43693ae9-0a95-4da7-834f-95493d162535
UUID:
uuid:43693ae9-0a95-4da7-834f-95493d162535
Local pid:
pubs:854347
Language:
English
Keywords:

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