The Listeria transcriptional landscape from saprophytism to virulence.

Journal article

The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered ...

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Authors: Toledo-Arana, A; Dussurget, O; Nikitas, G; Sesto, N; Guet-Revillet, H

• Journal: Nature
• Volume: 459
• Issue: 7249
• Pages: 950-956
• Publication date: 2009-06-01
• DOI: 10.1038/nature08080
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Gene Expression Regulation, Bacterial; Genes, Bacterial; Transcription, Genetic; Mice; Regulatory Sequences, Ribonucleic Acid; Genome, Bacterial; Virulence; Animals; Listeria monocytogenes; RNA, Bacterial; Intestines; Operon; Untranslated Regions; Open Reading Frames