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Journal article

Fluorine-directed diastereoselective iodocyclizations.

Abstract:
(Chemical Equation Presented) An inside job: β-Fluorinated lactones and tetrahydrofurans are synthesized by iodocyclization of various allylic fluorides. The fluorine substituent acts as a highly efficient syn-stereodirecting group for the ring closure. The experimental results combined with theoretical studies provide evidence in support of an "inside fluoro effect" to account for the sense and level of stereocontrol of these reactions. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200703465

Authors


Journal:
Angewandte Chemie (International ed. in English)
Volume:
47
Issue:
2
Pages:
357-360
Publication date:
2008-01-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Source identifiers:
34051
Language:
English
Keywords:
Pubs id:
pubs:34051
UUID:
uuid:432e56a3-5956-4340-80f9-49b39f4cf75c
Local pid:
pubs:34051
Deposit date:
2012-12-19

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