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The physiological action of gliclazide: beta-cell function and insulin resistance.

Abstract:

There is continuing debate about the physiological mechanisms of the action of sulphonylureas in man. In those patients taking sulphonylureas insulin secretion can be demonstrated to be higher, but there are also data which have been interpreted as evidence that these drugs may cause an alteration in peripheral insulin sensitivity. The physiological effects of the sulphonylurea gliclazide in diabetic subjects has been examined using a variety of experimental protocols to address this question...

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Publication status:
Published

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Authors


Matthews, DR More by this author
Hosker, JP More by this author
Stratton, I More by this author
Journal:
Diabetes research and clinical practice
Volume:
14 Suppl 2
Issue:
SUPPL. 2
Pages:
S53-S59
Publication date:
1991
DOI:
EISSN:
1872-8227
ISSN:
0168-8227
URN:
uuid:431d78ae-5a48-441e-96ef-a91a09b4b6f6
Source identifiers:
72824
Local pid:
pubs:72824

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