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Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments.

Abstract:

The need for successful ex-vivo expansion and directed differentiation of haematopoietic stem cells (HSCs) for therapeutic applications has increased over the past decade. Haematopoietic cell cultures are complex and full characterisation of the process environment has yet to be achieved. The complexity and transient nature of HSC cultures make the identification, maintenance and control of optimal operating conditions challenging. Application of real-time, on-line monitoring techniques and p...

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Authors


Panoskaltsis, N More by this author
Drakakis, EM More by this author
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Journal:
Biotechnology advances
Volume:
25
Issue:
4
Pages:
353-368
Publication date:
2007
DOI:
EISSN:
1873-1899
ISSN:
0734-9750
URN:
uuid:4310fa12-cf9b-4e76-aac2-419519b16300
Source identifiers:
317428
Local pid:
pubs:317428

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