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Coarse-grained simulations of DNA overstretching.

Abstract:

We use a recently developed coarse-grained model to simulate the overstretching of duplex DNA. Overstretching at 23 degrees C occurs at 74 pN in the model, about 6-7 pN higher than the experimental value at equivalent salt conditions. Furthermore, the model reproduces the temperature dependence of the overstretching force well. The mechanism of overstretching is always force-induced melting by unpeeling from the free ends. That we never see S-DNA (overstretched duplex DNA), even though there ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1063/1.4792252

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Institution:
University of Oxford
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Engineering and Physical Sciences Research Council More from this funder
University College More from this funder
Journal:
Journal of Chemical Physics Journal website
Volume:
138
Issue:
8
Pages:
Article: 085101
Publication date:
2013-02-28
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
URN:
uuid:430db1f3-25d6-4548-aaba-6abe5b029623
Source identifiers:
352667
Local pid:
pubs:352667

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