Journal article
Coarse-grained simulations of DNA overstretching.
- Abstract:
- We use a recently developed coarse-grained model to simulate the overstretching of duplex DNA. Overstretching at 23 degrees C occurs at 74 pN in the model, about 6-7 pN higher than the experimental value at equivalent salt conditions. Furthermore, the model reproduces the temperature dependence of the overstretching force well. The mechanism of overstretching is always force-induced melting by unpeeling from the free ends. That we never see S-DNA (overstretched duplex DNA), even though there is clear experimental evidence for this mode of overstretching under certain conditions, suggests that S-DNA is not simply an unstacked but hydrogen-bonded duplex, but instead probably has a more exotic structure.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
- Publisher:
- American Institute of Physics
- Journal:
- Journal of Chemical Physics More from this journal
- Volume:
- 138
- Issue:
- 8
- Article number:
- 085101
- Publication date:
- 2013-02-28
- DOI:
- EISSN:
-
1089-7690
- ISSN:
-
0021-9606
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:352667
- UUID:
-
uuid:430db1f3-25d6-4548-aaba-6abe5b029623
- Local pid:
-
pubs:352667
- Source identifiers:
-
352667
- Deposit date:
-
2013-09-26
Terms of use
- Copyright holder:
- American Institute of Physics
- Copyright date:
- 2013
- Notes:
- Copyright 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in J. Chem. Phys. 138, 085101 (2013) and may be found at http://link.aip.org/link/?jcp/138/085101
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