- Abstract:
-
In artery smooth muscle, adenylyl cyclase-coupled receptors such as beta-adrenoceptors evoke Ca(2+) signals, which open Ca(2+)-activated potassium (BK(Ca)) channels in the plasma membrane. Thus, blood pressure may be lowered, in part, through vasodilation due to membrane hyperpolarization. The Ca(2+) signal is evoked via ryanodine receptors (RyRs) in sarcoplasmic reticulum proximal to the plasma membrane. We show here that cyclic adenosine diphosphate-ribose (cADPR), by activating RyRs, media...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m204891200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 278
- Issue:
- 11
- Pages:
- 9602-9608
- Publication date:
- 2003-03-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:42ffcd68-5ff6-4618-8a84-85d33ef1e51f
- Source identifiers:
-
106374
- Local pid:
- pubs:106374
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose.
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