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Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose.

Abstract:

In artery smooth muscle, adenylyl cyclase-coupled receptors such as beta-adrenoceptors evoke Ca(2+) signals, which open Ca(2+)-activated potassium (BK(Ca)) channels in the plasma membrane. Thus, blood pressure may be lowered, in part, through vasodilation due to membrane hyperpolarization. The Ca(2+) signal is evoked via ryanodine receptors (RyRs) in sarcoplasmic reticulum proximal to the plasma membrane. We show here that cyclic adenosine diphosphate-ribose (cADPR), by activating RyRs, media...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m204891200

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Journal of biological chemistry
Volume:
278
Issue:
11
Pages:
9602-9608
Publication date:
2003-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
106374

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