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Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia.

Abstract:

BACKGROUND: We studied the outcome of individuals with aplastic anemia conditioned with a radiation-containing regimen followed by an infusion of stem cell grafts that had been depleted of lymphocytes with CAMPATH-1H (antiCD52; humanised). METHODS: The conditioning regime consisted of fractionated (f) TBI 8 Gy followed by f total nodal irradiation (TNI) 6 Gy. In addition, patients received CY 60 mg/kg on 2 consecutive days. Cytokine-mobilized peripheral blood grafts from HLA-identical sibling...

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Publication status:
Published

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Publisher copy:
10.1080/14653240410004970

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cytotherapy
Volume:
6
Issue:
5
Pages:
450-456
Publication date:
2004-01-01
DOI:
EISSN:
1477-2566
ISSN:
1465-3249
Source identifiers:
9312
Language:
English
Keywords:
Pubs id:
pubs:9312
UUID:
uuid:42991f85-0cbb-4bd6-8ef7-6c058082c569
Local pid:
pubs:9312
Deposit date:
2012-12-19

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