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Journal article

Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.

Abstract:

Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlated the efficacy of chlorproguanil-dapsone plus artesunate (CPG-DDS+A) and amodiaquine plus sulfadoxine-pyrimethamine (AQ+SP) in children with uncomplicated malaria caused by Plas...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00498-09

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
54
Issue:
1
Pages:
477-483
Publication date:
2010-01-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:427f7c53-34af-4650-8670-247ee0d0bd94
Source identifiers:
9585
Local pid:
pubs:9585

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