- Abstract:
-
Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlated the efficacy of chlorproguanil-dapsone plus artesunate (CPG-DDS+A) and amodiaquine plus sulfadoxine-pyrimethamine (AQ+SP) in children with uncomplicated malaria caused by Plas...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.00498-09
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 54
- Issue:
- 1
- Pages:
- 477-483
- Publication date:
- 2010-01-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:427f7c53-34af-4650-8670-247ee0d0bd94
- Source identifiers:
-
9585
- Local pid:
- pubs:9585
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.
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