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G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

Abstract:

Suppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang2-/-) mice. Surprisingly, the metastatic colonies formed in Ang2-/- mice were larger than those in the wild type. These colonies had greater vascular density wi...

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Publisher copy:
10.1002/ijc.27677

Authors


Tapmeier, T More by this author
Balathasan, L More by this author
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Journal:
International Journal of Cancer
Volume:
132
Issue:
2
Pages:
315-326
Publication date:
2013-01-15
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:427f5c17-6ece-4141-a54b-d21f3a245123
Source identifiers:
365354
Local pid:
pubs:365354

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