Conference item

A new role for RGS-1 in vascular function and blood pressure regulation

Abstract:: The Regulator of G-Protein Signalling-1 (RGS1) controls G protein coupled receptor signalling by acting as a GTPase-activating protein for heterotrimeric G proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. We have previously shown that Rgs1 regulates macrophage accumulation in Angiotensin II (Ang II)-induced aortic aneurysms and Rgs1-/-ApoE-/- mice are protected from Ang II-induced aortic aneurysm rupture compared to ApoE-/- mice. Conversely, Ang II treatment increases systolic blood pressure to a greater extent in Rgs1-/-ApoE-/- mice than ApoE-/- mice and this is mediated by non-haematopoietic cells as indicated by bone marrow chimeras. However the precise role of RGS1 in hypertension and vascular-derived cells is unknown.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Patel, J., Chuaiphichai, S., Douglas, G., & Channon, K. (2018). A new role for RGS-1 in vascular function and blood pressure regulation. Frontiers in CardioVascular Biology 2018.

MLA Style

Patel, J., et al. “A New Role for RGS-1 in Vascular Function and Blood Pressure Regulation.” Frontiers in CardioVascular Biology 2018, Oxford University Press, 2018.

Chicago Style

Patel, J, S Chuaiphichai, G Douglas, and K Channon. 2018. “A New Role for RGS-1 in Vascular Function and Blood Pressure Regulation.” In Frontiers in CardioVascular Biology 2018. Oxford University Press.
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Publisher copy:: 10.1093/cvr/cvy060.254

Authors

+ Patel, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: RDM Cardiovascular Medicine
Role:: Author

+ Chuaiphichai, S More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: RDM; RDM Cardiovascular Medicine
Role:: Author

+ Douglas, G More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: RDM; RDM Cardiovascular Medicine
Role:: Author

+ Channon, K More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: RDM; RDM Cardiovascular Medicine
Oxford college:: Exeter College
Role:: Author
ORCID:: 0000-0002-1043-4342

+ British Heart Foundation More from this funder

Grant:: PG/15/35/31403

Publisher:: Oxford University Press
Host title:: Frontiers in CardioVascular Biology 2018
Journal:: Frontiers in CardioVascular Biology 2018 More from this journal
Publication date:: 2018-04-23
DOI:: 10.1093/cvr/cvy060.254

Pubs id:: pubs:846772
UUID:: uuid:42304be4-898c-4036-8793-d3215022f81c
Local pid:: pubs:846772
Source identifiers:: 846772
Deposit date:: 2018-07-24

Terms of use

Copyright date:: 2018

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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