Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against v...Expand abstract
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- Author(s) retain copyright; published by Nature Publishing Group under license. Molecular Therapy is the official journal of the American Society of Gene and Cell Therapy. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors.
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