- Abstract:
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Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against v...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.8MB)
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- Publisher copy:
- 10.1038/mt.2016.114
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Mol Ther Journal website
- Publication date:
- 2016-07-12
- DOI:
- EISSN:
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1525-0024
- ISSN:
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1525-0016
- URN:
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uuid:42207a3c-4604-4149-b94c-f83bdedfea0e
- Source identifiers:
-
633896
- Local pid:
- pubs:633896
- Language:
- English
- Copyright holder:
- Yang et al.
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group under license. Molecular Therapy is the official journal of the American Society of Gene and Cell Therapy. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal article
Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors.
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NIHR Oxford Biomedical Research Centre
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