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Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors.

Abstract:

Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against v...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mt.2016.114

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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NIHR Oxford Biomedical Research Centre More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Mol Ther Journal website
Publication date:
2016-07-12
Acceptance date:
2016-05-24
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Source identifiers:
633896
Language:
English
Pubs id:
pubs:633896
UUID:
uuid:42207a3c-4604-4149-b94c-f83bdedfea0e
Local pid:
pubs:633896
Deposit date:
2016-07-13

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