Journal article
Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial
- Abstract:
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Background: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hyp... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.7MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pmed.1002706
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS Medicine More from this journal
- Volume:
- 15
- Issue:
- 12
- Article number:
- e1002706
- Publication date:
- 2018-12-04
- Acceptance date:
- 2018-10-29
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- Pubs id:
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pubs:935242
- UUID:
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uuid:4212117c-9bbd-4c68-9e56-ff9bd1ae38a3
- Local pid:
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pubs:935242
- Source identifiers:
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935242
- Deposit date:
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2018-10-29
- ARK identifier:
Terms of use
- Copyright holder:
- Kityo et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Kityo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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