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Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial

Abstract:
Background: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hyp... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002706

Authors


Szubert, A More by this author
Heydermann, R More by this author
Bwakura-Dangarembizi, M More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
15
Issue:
12
Pages:
Article: e1002706
Publication date:
2018-12-04
Acceptance date:
2018-10-29
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:935242
URN:
uri:4212117c-9bbd-4c68-9e56-ff9bd1ae38a3
UUID:
uuid:4212117c-9bbd-4c68-9e56-ff9bd1ae38a3
Local pid:
pubs:935242

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