Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.

Journal article

A genome-wide association study (GWAS) using pooled DNA samples from 386 sporadic ALS patients and 542 controls from the USA, identified genetic variation in FGGY (FLJ10986) as a risk factor, as well as 66 additional candidate SNPs. Considering the large number of hypotheses that are tested in GWAS, independent replication of associations is crucial for identifying true-positive genetic risk factors for disease. The primary aim of this study was to study the association between FGGY and spora...

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Authors: Es, V; Van Vught, P; Veldink, J; Andersen, P; Birve, A

• Publication status: Published
• Journal: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
• Volume: 10
• Issue: 5-6
• Pages: 441-447
• Publication date: 2009-01-01
• DOI: 10.3109/17482960802673042
• EISSN: 1471-180X
• ISSN: 1748-2968
• Language: English
• Keywords: Genome-Wide Association Study; Amyotrophic Lateral Sclerosis; Female; Population Groups; Male; Genetic Variation; Europe; Humans; Genome, Human; Genetic Predisposition to Disease; Risk Factors; Genetics, Population; Polymorphism, Single Nucleotide; Proteins