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A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction

Abstract:

Little is known about the intermolecular dynamics and stoichiometry of the interactions of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein with its receptors and co-receptors on the host cell surface. Here we analyze timeresolved HIV-1 Env interactions with T-cell surface glycoprotein CD4 (CD4) and C-C chemokine receptor type 5 (CCR5) or C-X-C chemokine receptor type 4 (CXCR4) on the surface of cells, by combining multicolor super-resolution localization microscopy (dir...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41594-018-0113-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
MSD Doctoral Training Centre
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
ORCID:
0000-0003-1316-1906
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
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Grant:
Oxford-Cambridge Fellowship
Nuffield Department of Medicine More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
25
Issue:
9
Pages:
814-822
Publication date:
2018-08-27
Acceptance date:
2018-07-13
DOI:
ISSN:
1545-9985 and 1545-9993
Pubs id:
pubs:911213
URN:
uri:41fbbc48-a027-4d71-a37d-a47ae3d114ab
UUID:
uuid:41fbbc48-a027-4d71-a37d-a47ae3d114ab
Local pid:
pubs:911213
Language:
English
Keywords:

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