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In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's disease

Abstract:

Many neurodegenerative diseases are characterized by amyloid deposition. In Alzheimer's disease (AD), β-amyloid (Aβ) peptides accumulate extracellularly in senile plaques. The AD amyloid cascade hypothesis proposes that Aβ production or reduced clearance leads to toxicity. In contrast, the cholinergic hypothesis argues for a specific pathology of brain cholinergic pathways. However, neither hypothesis in isolation explains the pattern of AD pathogenesis. Evidence suggests that a connection ex...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra118.006230

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Role:
Author
ORCID:
0000-0002-6450-7148
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0002-4901-9795
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
294
Issue:
16
Pages:
6253-6272
Publication date:
2019-04-19
Acceptance date:
2019-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
30787102
Source identifiers:
977376
Language:
English
Keywords:
Pubs id:
pubs:977376
UUID:
uuid:41f7371a-5d23-4eaf-8bf8-3c154ad9cb92
Local pid:
pubs:977376
Deposit date:
2019-04-24

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