Thesis
The roles of phosphocholine expressed on NTHi bacteria and host CRP in acute otitis media
- Abstract:
-
Otitis Media (OM) is inflammation of the middle ear (ME). Non-typeable Haemophilus influenzae (NTHi) is one of the leading otopathogens causing OM. Phosphocholine (PCho) on the NTHi lipopolysaccharide influences host-pathogen interaction. C-Reactive Protein (CRP), an acute phase protein, recognizes PCho and can mediate bacterial killing. However, some strains of NTHi survive well in the presence of CRP. We aimed to study the interaction of CRP with NTHi to understand its role in bacter...
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Authors
Contributors
+ Hood, D
Role:
Supervisor
+ Hinks, T
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Supervisor
Funding
+ Medical Research Council
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2023-08-31
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Terms of use
- Copyright holder:
- Bharj, GK
- Copyright date:
- 2022
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