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Breaking the allergic response by disrupting antibody glycosylation

Abstract:

Allergic reactions arise when people become sensitized to otherwise harmless environmental antigens. In this issue, Shade et al. reveal that the immunoglobulin ε (IgE) antibodies that mediate these reactions have a key vulnerability. They report that the ability of IgE to trigger an allergic reaction through its interaction with mast cells is dependent on a single site of antibody glycosylation. With the in vivo targeting of specific glycoprotein glycans emerging as a viable strategy for modu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1084/jem.2124insight2

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
212
Issue:
4
Pages:
433-433
Publication date:
2015-04-06
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:41ddf6e5-88ab-4689-9147-a0c5c381e11f
Source identifiers:
604652
Local pid:
pubs:604652

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