Journal article
Breaking the allergic response by disrupting antibody glycosylation
- Abstract:
- Allergic reactions arise when people become sensitized to otherwise harmless environmental antigens. In this issue, Shade et al. reveal that the immunoglobulin ε (IgE) antibodies that mediate these reactions have a key vulnerability. They report that the ability of IgE to trigger an allergic reaction through its interaction with mast cells is dependent on a single site of antibody glycosylation. With the in vivo targeting of specific glycoprotein glycans emerging as a viable strategy for modulating endogenous glycoprotein function, these findings are of significant interest.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.2MB, Terms of use)
-
- Publisher copy:
- 10.1084/jem.2124insight2
Authors
- Publisher:
- Rockefeller University Press
- Journal:
- Journal of Experimental Medicine More from this journal
- Volume:
- 212
- Issue:
- 4
- Pages:
- 433-433
- Publication date:
- 2015-04-06
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- Pubs id:
-
pubs:604652
- UUID:
-
uuid:41ddf6e5-88ab-4689-9147-a0c5c381e11f
- Local pid:
-
pubs:604652
- Source identifiers:
-
604652
- Deposit date:
-
2016-02-17
Terms of use
- Copyright holder:
- Crispin, M
- Copyright date:
- 2015
- Notes:
- © 2015 Crispin. This is the publisher's version of the article. The final version is available online from Rockefeller University Press at: [10.1084/jem.2124insight2]
If you are the owner of this record, you can report an update to it here: Report update to this record