Journal article
Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?
- Abstract:
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Cardiac electrophysiology models have been developed for over 50 years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, with quantities such as ion channel kinetics or expression levels being difficult to measure or variable between samples. Until recently, the original approach of describing model parameters using single values has been retained, and consequently th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Version of record, pdf, 2.6MB, Terms of use)
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- Publisher copy:
- 10.1016/j.yjmcc.2015.11.018
Authors
Funding
+ National Centre for the Replacement, Refinement and Reduction of Animals in Research
More from this funder
Grant:
NC/K001337/1
+ Engineering and Physical Sciences Research Council
More from this funder
Grant:
1366641
EP/I017909/1
EP/K037145/1
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Journal of Molecular and Cellular Cardiology More from this journal
- Volume:
- 96
- Pages:
- 49-62
- Publication date:
- 2015-12-02
- Acceptance date:
- 2015-11-17
- DOI:
- EISSN:
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1095-8584
- ISSN:
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0022-2828
- Pmid:
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26611884
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:575109
- UUID:
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uuid:41ca89d2-f6f2-4614-bd22-43b4ef7ddfdf
- Local pid:
-
pubs:575109
- Source identifiers:
-
575109
- Deposit date:
-
2018-04-04
Terms of use
- Copyright holder:
- Johnstone et al
- Copyright date:
- 2015
- Notes:
- © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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