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Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

Abstract:

Cardiac electrophysiology models have been developed for over 50 years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. It is commonly accepted that there are many uncertainties in these systems, with quantities such as ion channel kinetics or expression levels being difficult to measure or variable between samples. Until recently, the original approach of describing model parameters using single values has been retained, and consequently th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.yjmcc.2015.11.018

Authors


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Role:
Author
ORCID:
0000-0002-1097-4189
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Role:
Author
ORCID:
0000-0002-0561-6491
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Department of Computer Science
Oxford college:
New College
Role:
Author
ORCID:
0000-0001-8311-3200
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular and Cellular Cardiology Journal website
Volume:
96
Pages:
49-62
Publication date:
2015-12-02
Acceptance date:
2015-11-17
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Pubs id:
pubs:575109
URN:
uri:41ca89d2-f6f2-4614-bd22-43b4ef7ddfdf
UUID:
uuid:41ca89d2-f6f2-4614-bd22-43b4ef7ddfdf
Local pid:
pubs:575109

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