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Effects of MACPF/CDC proteins on lipid membranes.

Abstract:

Recent work on the MACPF/CDC superfamily of pore-forming proteins has focused on the structural analysis of monomers and pore-forming oligomeric complexes. We set the family of proteins in context and highlight aspects of their function which the direct and exclusive equation of oligomers with pores fails to explain. Starting with a description of the distribution of MACPF/CDC proteins across the domains of life, we proceed to show how their evolutionary relationships can be understood on the...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-012-1153-8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Dalla Serra, M More by this author
Froelich, CJ More by this author
Anderluh, G More by this author
Journal:
Cellular and molecular life sciences : CMLS
Volume:
70
Issue:
12
Pages:
2083-2098
Publication date:
2013-06-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:41aa0f5d-137f-4591-beab-f9ee242bfc68
Source identifiers:
352415
Local pid:
pubs:352415

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