Journal article icon

Journal article

The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

Abstract:

Antigenic variation in the human malaria parasite Plasmodium falciparum involves sequential and mutually exclusive expression of members of the var multi-gene family and appears to follow a non-random pattern. In this study, using a detailed in vitro gene transcription analysis of the culture-adapted HB3 strain of P. falciparum, we show that antigenic switching is governed by a global activation hierarchy favouring short and highly diverse genes in central chromosomal location. Longer and mor...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.7554/elife.01074

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Expand authors...
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2013
Issue:
2
Pages:
Article: e01074
Publication date:
2013-09-17
Acceptance date:
2013-08-19
DOI:
EISSN:
2050-084X
URN:
uuid:41912074-3ced-4cb8-94d0-779b2212d944
Source identifiers:
431079
Local pid:
pubs:431079

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP