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Journal article

A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Abstract:

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of Y...

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Publication status:
Published

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Publisher copy:
10.1126/science.1219179

Authors


Gomez Perdiguero, E More by this author
Szabo-Rogers, H More by this author
Cagnard, N More by this author
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Journal:
Science (New York, N.Y.)
Volume:
336
Issue:
6077
Pages:
86-90
Publication date:
2012-04-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:4181d4fa-99e8-4eac-9ec3-450d5fcbfad7
Source identifiers:
321616
Local pid:
pubs:321616

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