Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors.

Journal article

To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations...

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Authors: Reinis, M; Weiser, B; Kuiken, C; Dong, T; Lang, D

• Journal: AIDS research and human retroviruses
• Volume: 23
• Issue: 2
• Pages: 309-315
• Publication date: 2007-02-01
• DOI: 10.1089/aid.2006.0180
• EISSN: 1931-8405
• ISSN: 0889-2229
• Language: English
• Keywords: HIV Long-Term Survivors; Infant, Newborn; Selection, Genetic; HIV Infections; Female; Molecular Sequence Data; Adult; Pregnancy; HIV-1; Infectious Disease Transmission, Vertical; Child, Preschool; Evolution, Molecular; Disease Progression; Humans; Retroviridae Proteins; Gene Products, nef; nef Gene Products, Human Immunodeficiency Virus; Genes, MHC Class I