Journal article

Crystal Structure of Sphingosine Kinase 1 with PF-543.

Abstract:: The most potent inhibitor of Sphingosine Kinase 1 (SPHK1) so far identified is PF-543. The crystal structure of SPHK1 in complex with inhibitor PF-543 to 1.8 Å resolution reveals the inhibitor bound in a bent conformation analogous to that expected of a bound sphingosine substrate but with a rotated head group. The structural data presented will aid in the design of SPHK1 and SPHK2 inhibitors with improved properties.

Publication status:: Published

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APA Style

Wang, J., Knapp, S., Pyne, N., Pyne, S., & Elkins, J. (2014). Crystal Structure of Sphingosine Kinase 1 with PF-543. ACS Medicinal Chemistry Letters, 5(12), 1329–1333.

MLA Style

Wang, J., et al. “Crystal Structure of Sphingosine Kinase 1 with PF-543.” ACS Medicinal Chemistry Letters, vol. 5, no. 12, American Chemical Society, 2014, pp. 1329–33.

Chicago Style

Wang, J, S Knapp, N Pyne, S Pyne, and J Elkins. 2014. “Crystal Structure of Sphingosine Kinase 1 with PF-543.” ACS Medicinal Chemistry Letters 5 (12): 1329–33.
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Publisher copy:: 10.1021/ml5004074

Authors

+ Wang, J More by this author

Role:: Author

+ Knapp, S More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Genomics Consortium
Role:: Author

+ Pyne, N More by this author

Role:: Author

+ Pyne, S More by this author

Role:: Author

+ Elkins, J More by this author

Role:: Author

Publisher:: American Chemical Society
Journal:: ACS medicinal chemistry letters More from this journal
Volume:: 5
Issue:: 12
Pages:: 1329-1333
Publication date:: 2014-12-01
DOI:: 10.1021/ml5004074
EISSN:: 1948-5875
ISSN:: 1948-5875

Language:: English
Keywords:: SPHK2

sphingosine

SPHK1

S1P

lipid

PF-543
Pubs id:: pubs:499830
UUID:: uuid:41340312-7b29-4265-9ddd-e2d1cb984583
Local pid:: pubs:499830
Source identifiers:: 499830
Deposit date:: 2015-01-19

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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