- Abstract:
- The most potent inhibitor of Sphingosine Kinase 1 (SPHK1) so far identified is PF-543. The crystal structure of SPHK1 in complex with inhibitor PF-543 to 1.8 Å resolution reveals the inhibitor bound in a bent conformation analogous to that expected of a bound sphingosine substrate but with a rotated head group. The structural data presented will aid in the design of SPHK1 and SPHK2 inhibitors with improved properties.
- Publication status:
- Published
- Publisher copy:
- 10.1021/ml5004074
-
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- Publisher:
- American Chemical Society
- Journal:
- ACS medicinal chemistry letters
- Volume:
- 5
- Issue:
- 12
- Pages:
- 1329-1333
- Publication date:
- 2014-12-05
- DOI:
- EISSN:
-
1948-5875
- ISSN:
-
1948-5875
- URN:
-
uuid:41340312-7b29-4265-9ddd-e2d1cb984583
- Source identifiers:
-
499830
- Local pid:
- pubs:499830
- Copyright date:
- 2014
Journal article
Crystal Structure of Sphingosine Kinase 1 with PF-543.
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