Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles

Journal article

Highly efficient CTC isolation technique based on peptide-magnetic nanoparticles was firstly applied in NSCLC patients. Compared with the antibody-based the technique, the higher CTC detection rates (71.4%) in NSCLC patient blood samples were demonstrated for the patients in different stages, I-IV, especially in early stages. This indicates the feasibility of the clinical utility of this new technique in early stage screening, prognosis and therapy evaluation of NSCLC.

Authors: Liang, N; Liu, L; Li, P; Xu, Y; Hou, Y

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: AME Publishing
• Journal: Journal of Thoracic Disease
• Volume: 12
• Issue: 8
• Pages: 4262-4273
• Publication date: 2020-08-01
• DOI: 10.21037/jtd-20-1026a
• EISSN: 2077-6624
• ISSN: 2072-1439
• Language: English
• Keywords: Medicine; Antibody; Metastasis; Lung cancer; A549 cell; Circulating tumor cell; Oncology; Internal medicine; Epithelial cell adhesion molecule; Chemistry; Peptide; Cancer research; Cancer; Biochemistry; Immunology