Journal article icon

Journal article

Algebraic systems biology: a case study for the Wnt pathway

Abstract:

Steady state analysis of dynamical systems for biological networks give rise to algebraic varieties in high-dimensional spaces whose study is of interest in their own right. We demonstrate this for the shuttle model of the Wnt signaling pathway. Here the variety is described by a polynomial system in 19 unknowns and 36 parameters. It has degree 9 over the parameter space. This case study explores multistationarity, model comparison, dynamics within regions of the state space, identifiability ...

Expand abstract
Publication status:
Accepted
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Institute
Sturmfels, B More by this author
Publisher:
Springer US Publisher's website
Journal:
Bulletin of Mathematical Biology Journal website
Publication date:
2015
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:41141d9d-fef3-48ab-afb9-3caad2426c5d
Source identifiers:
574648
Local pid:
pubs:574648

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP