Molecular mechanism of lipopeptide presentation by CD1a.

Journal article

CD1a is expressed on Langerhans cells (LCs) and dendritic cells (DCs), where it mediates T cell recognition of glycolipid and lipopeptide antigens that contain either one or two alkyl chains. We demonstrate here that CD1a-restricted T cells can discriminate the peptide component of didehydroxymycobactin lipopeptides. Structure analysis of CD1a cocrystallized with a synthetic mycobactin lipopeptide at 2.8 A resolution further reveals that the single alkyl chain is inserted deep within the A' p...

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Authors: Zajonc, D; Crispin, MD; Bowden, T; Young, D; Cheng, T

• Publication status: Published
• Journal: Immunity
• Volume: 22
• Issue: 2
• Pages: 209-219
• Publication date: 2005-02-01
• DOI: 10.1016/j.immuni.2004.12.009
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Sulfoglycosphingolipids; Antigen Presentation; Cells, Cultured; Oxazoles; Crystallization; Humans; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Substrate Specificity; Antigens, CD1; Ligands; Protein Binding; Lipoproteins; Lymphocyte Activation; Receptors, Antigen, T-Cell; Peptides; Protein Conformation; T-Lymphocytes