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Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.

Abstract:

Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recog...

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Publication status:
Published

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Authors


Swainson, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Sahakian, BJ More by this author
Summers, BA More by this author
Polkey, CE More by this author
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Journal:
Neuropsychologia
Volume:
38
Issue:
5
Pages:
596-612
Publication date:
2000
DOI:
EISSN:
1873-3514
ISSN:
0028-3932
URN:
uuid:40ed2eb3-4958-414d-a31c-bcceac7485ad
Source identifiers:
223174
Local pid:
pubs:223174

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