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Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.

Abstract:

Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recog...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Journal:
Neuropsychologia
Volume:
38
Issue:
5
Pages:
596-612
Publication date:
2000-01-01
DOI:
EISSN:
1873-3514
ISSN:
0028-3932
Source identifiers:
223174

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