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Oral contraceptive use and risk of liver cancer: a population-based study, systematic review, and meta-analysis

Abstract:
Background:
Oral contraceptive use has been suggested to increase the risk of liver cancer. Although the International Agency for Research on Cancer concluded in 1999 that there was sufficient evidence of an association, this was based on case-control studies with few liver cancer cases. We aimed to provide more robust epidemiological evidence on this association by analysing data from two large prospective UK cohorts and additionally conducting a systematic review and me... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1470-2045(25)00222-0

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
ORCID:
0000-0001-8864-4684


More from this funder
Funder identifier:
https://ror.org/054225q67
Grant:
A29186
More from this funder
Funder identifier:
https://ror.org/01gavpb45
Grant:
187861


Publisher:
Elsevier
Journal:
Lancet Oncology More from this journal
Volume:
26
Issue:
8
Pages:
1031-1042
Place of publication:
England
Publication date:
2025-07-03
Acceptance date:
2025-04-10
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
Pmid:
40617239


Language:
English
Pubs id:
2134428
Local pid:
pubs:2134428
Deposit date:
2025-07-29
ARK identifier:

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