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Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial

Abstract:

Background Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi Arabia. MERS-CoV poses a significant risk to public health security because of an absence of currently available effective countermeasures. We aimed to assess the safety and immunogenicity of the candidate simian adenovirus-vectored vaccine expressing the full-length spike surface glycoprotein, ChAdOx1...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1016/S1473-3099(20)30160-2

Authors


More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author


Publisher:
Elsevier
Journal:
Lancet Infectious Diseases More from this journal
Volume:
20
Issue:
7
Pages:
816-826
Publication date:
2020-04-21
Acceptance date:
2020-02-28
DOI:
EISSN:
1474-4457
ISSN:
1473-3099


Language:
English
Keywords:
Pubs id:
1096129
Local pid:
pubs:1096129
Deposit date:
2020-03-24

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