Journal article
Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial
- Abstract:
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Background Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi Arabia. MERS-CoV poses a significant risk to public health security because of an absence of currently available effective countermeasures. We aimed to assess the safety and immunogenicity of the candidate simian adenovirus-vectored vaccine expressing the full-length spike surface glycoprotein, ChAdOx1...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Supplementary materials, Version of record, 2.8MB, Terms of use)
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- Publisher copy:
- 10.1016/S1473-3099(20)30160-2
Authors
- Publisher:
- Elsevier
- Journal:
- Lancet Infectious Diseases More from this journal
- Volume:
- 20
- Issue:
- 7
- Pages:
- 816-826
- Publication date:
- 2020-04-21
- Acceptance date:
- 2020-02-28
- DOI:
- EISSN:
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1474-4457
- ISSN:
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1473-3099
- Language:
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English
- Keywords:
- Pubs id:
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1096129
- Local pid:
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pubs:1096129
- Deposit date:
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2020-03-24
Terms of use
- Copyright holder:
- Folegatti et al.
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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