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The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.

Abstract:

The RAG1 and RAG2 proteins are the only lymphoid-specific factors required to perform the first step of V(D)J recombination, DNA cleavage. While the catalytic domain of RAG1, the core region, has been well characterized, the role of the noncore region in modulating chromosomal V(D)J recombination efficiency remains ill defined. Recent studies have highlighted the role of chromatin structure in regulation of V(D)J recombination. Here we show that RAG1 itself, through a RING domain within its N...

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Publication status:
Published

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Authors


Grazini, U More by this author
Zanardi, F More by this author
Citterio, E More by this author
Goding, CR More by this author
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Journal:
Molecular cell
Volume:
37
Issue:
2
Pages:
282-293
Publication date:
2010-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:40b01339-70b3-4d76-81df-25593b4dc58a
Source identifiers:
53955
Local pid:
pubs:53955

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