- Abstract:
-
The RAG1 and RAG2 proteins are the only lymphoid-specific factors required to perform the first step of V(D)J recombination, DNA cleavage. While the catalytic domain of RAG1, the core region, has been well characterized, the role of the noncore region in modulating chromosomal V(D)J recombination efficiency remains ill defined. Recent studies have highlighted the role of chromatin structure in regulation of V(D)J recombination. Here we show that RAG1 itself, through a RING domain within its N...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.molcel.2009.12.035
-
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- Journal:
- Molecular cell
- Volume:
- 37
- Issue:
- 2
- Pages:
- 282-293
- Publication date:
- 2010-01-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:40b01339-70b3-4d76-81df-25593b4dc58a
- Source identifiers:
-
53955
- Local pid:
- pubs:53955
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
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