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The effect of interactions on the cellular uptake of nanoparticles

Abstract:

We present a simple two-state model to understand the size-dependent endocytosis of nanoparticles. Using this model, we elucidate the relevant energy terms required to understand the size-dependent uptake mechanism and verify it by correctly predicting the behavior at large and small particle sizes. In the absence of interactions between the nanoparticles, we observe an asymmetric distribution of sizes with maximum uptake at intermediate sizes and a minimum size cut-off below which there can ...

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Authors


Chaudhuri, A More by this author
Battaglia, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Journal:
Physical Biology
Volume:
8
Issue:
4
Publication date:
2011-08-05
DOI:
EISSN:
1478-3975
ISSN:
1478-3967
URN:
uuid:40766092-6b81-4ead-8eeb-2b6cb65aace3
Source identifiers:
179251
Local pid:
pubs:179251
Language:
English

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