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Journal article

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

Abstract:

DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF from patients with resolving arthritis, fully established RA and from non-arthritic patients. DNA was hybridized to Infinium Human methylation 450k and 850k arrays and differential methylated genes and pathways were identified. We could identify a signific...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-24240-2

Authors


Karouzakis, E More by this author
Kolling, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
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Innovative Medicine Initiative More from this funder
Institute for Arthritis Research Epalinges More from this funder
Greek General Secretariat for Research and Technology More from this funder
European Social Fund More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
7370
Publication date:
2018-05-09
Acceptance date:
2018-03-26
DOI:
EISSN:
2045-2322
Pubs id:
pubs:847820
URN:
uri:4051205e-066e-4c6a-886d-cd7a0588a816
UUID:
uuid:4051205e-066e-4c6a-886d-cd7a0588a816
Local pid:
pubs:847820

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