- Abstract:
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DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF from patients with resolving arthritis, fully established RA and from non-arthritic patients. DNA was hybridized to Infinium Human methylation 450k and 850k arrays and differential methylated genes and pathways were identified. We could identify a signific...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1mb)
-
- Publisher copy:
- 10.1038/s41598-018-24240-2
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- 7370
- Publication date:
- 2018-05-09
- Acceptance date:
- 2018-03-26
- DOI:
- EISSN:
-
2045-2322
- Pubs id:
-
pubs:847820
- URN:
-
uri:4051205e-066e-4c6a-886d-cd7a0588a816
- UUID:
-
uuid:4051205e-066e-4c6a-886d-cd7a0588a816
- Local pid:
- pubs:847820
- Copyright holder:
- Buckley et al
- Copyright date:
- 2018
- Notes:
-
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
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Innovative Medicine Initiative
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EuroTEAM
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Institute for Arthritis Research Epalinges
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Greek General Secretariat for Research and Technology
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European Social Fund
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