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A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function.

Abstract:

Tumor necrosis factor-stimulated gene-6 (TSG-6) is an inflammation-associated hyaluronan (HA)-binding protein that contributes to remodeling of HA-rich extracellular matrices during inflammatory processes and ovulation. The HA-binding domain of TSG-6 consists solely of a Link module, making it a prototypical member of the superfamily of proteins that interacts with this high molecular weight polysaccharide composed of repeating disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine (Gl...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.542357

Authors


Higman, VA More by this author
Briggs, DC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Blundell, CD More by this author
Sattelle, BM More by this author
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Journal:
The Journal of biological chemistry
Volume:
289
Issue:
9
Pages:
5619-5634
Publication date:
2014-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:404384b1-132a-49ab-862c-efa6b64e2542
Source identifiers:
445863
Local pid:
pubs:445863

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