Immunogen design to focus the B-cell repertoire.

Journal article

PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.

Authors: Sattentau, Q

• Publication status: Published
• Journal: Current opinion in HIV and AIDS
• Volume: 9
• Issue: 3
• Pages: 217-223
• Publication date: 2014-05-01
• DOI: 10.1097/coh.0000000000000054
• EISSN: 1746-6318
• ISSN: 1746-630X
• Language: English
• Keywords: Humans; HIV Infections; HIV Antibodies; B-Lymphocytes; Antibodies, Neutralizing; HIV Envelope Protein gp120