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Journal article

Immunogen design to focus the B-cell repertoire.

Abstract:

PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and gly...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Current opinion in HIV and AIDS
Volume:
9
Issue:
3
Pages:
217-223
Publication date:
2014-05-01
DOI:
EISSN:
1746-6318
ISSN:
1746-630X
Language:
English
Keywords:
Pubs id:
pubs:458606
UUID:
uuid:40385091-07ad-4800-a741-b847bbd70c9b
Local pid:
pubs:458606
Source identifiers:
458606
Deposit date:
2014-06-17

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