Effectiveness of Umonium38 against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA)

Journal article

Aims
We investigated the antibacterial efficacy of Umonium³⁸ and Virkon^® against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) up to 14 days following treatment.
Methods and results
Umonium³⁸ was diluted to 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3%, tested against the bacterial strains at various contact times (15 min to 24 h), and incubated for up to 14 days. A minimum concentration of 0.5% Umonium³⁸ with a contact time of 15 min effectively killed approximately 10⁸ CFU/ml of all four bacterial species. No growth was observed on agar plates from day 0 until day 14 for all six concentrations. The bacteria were also inactivated by a 30-minute treatment time using Virkon^® 1% solution.
Conclusions
Umonium³⁸ effectively inactivates B. pseudomallei, E. coli, P. aeruginosa and MRSA at a concentration of ≥ 0.5% with a contact time of at least 15 min. The antimicrobial effect of Umonium³⁸ remained for 14 days.

Authors: Ruanchaiman, S; Amornchai, P; Wuthiekanun, V; Langla, S; Maroongruang, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: BMC Infectious Diseases
• Volume: 24
• Issue: 1
• Article number: 212
• Place of publication: England
• Publication date: 2024-02-16
• Acceptance date: 2024-02-05
• DOI: 10.1186/s12879-024-09102-9
• EISSN: 1471-2334
• Pmid: 38365598
• Language: English
• Keywords: bacterial viability; Umonium38; disinfectant; virkon