Journal article
Scaffolding the attention-deficit/hyperactivity disorder brain using transcranial direct current and random noise stimulation: a randomized controlled trial
- Abstract:
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Objective
Improving symptomology and cognitive deficits in neurodevelopmental disorders is a crucial challenge. We examined whether neurostimulation protocols, which have been shown to yield long-term effects when combined with cognitive training, could benefit children with Attention-deficit/hyperactivity-disorder (ADHD), the most common neurodevelopmental disorder in childhood.Methods
We used a randomized double-blind active-controlled crossover study of 19 unmedicated children with ADHD, who received either anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (dlPFC) or random noise stimulation (tRNS) over the bilateral dlPFC, while completing executive functions training.Results
For our primary outcome, tRNS yielded a clinical improvement as indicated by the reduced ADHD rating-scale score from baseline, and in comparison to the changes observed in tDCS. The effect of brain stimulation one week after completion of treatment yielded further improvement, suggesting a neuroplasticity-related effect. Finally, tRNS improved working memory compared to tDCS, and a larger tRNS effect on ADHD rating-scale was predicted for those who showed the greatest improvement in working memory.Conclusions
We found that our intervention can have a lasting effect, rather than a merely immediate effect as was shown for in previous medical interventions in ADHD.Significance
Our results provide a promising direction toward a novel intervention in ADHD.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1016/j.clinph.2021.01.005
Authors
- Publisher:
- Elsevier
- Journal:
- Clinical Neurophysiology More from this journal
- Volume:
- 132
- Issue:
- 3
- Pages:
- 699-707
- Publication date:
- 2021-07-27
- Acceptance date:
- 2021-01-08
- DOI:
- ISSN:
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1388-2457
- Language:
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English
- Keywords:
- Pubs id:
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1152606
- Local pid:
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pubs:1152606
- Deposit date:
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2021-01-08
Terms of use
- Copyright holder:
- International Federation of Clinical Neurophysiology
- Copyright date:
- 2021
- Rights statement:
- © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.clinph.2021.01.005
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