Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.

Journal article

Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with di...

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Authors: Thananchai, H; Gillespie, G; Martin, M; Bashirova, A; Yawata, N

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 178
• Issue: 1
• Pages: 33-37
• Publication date: 2007-01-01
• DOI: 10.4049/jimmunol.178.1.33
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Receptors, KIR3DL1; Receptors, KIR; Alleles; HLA-B Antigens; Receptors, Immunologic; Humans; Killer Cells, Natural; Histocompatibility Antigens Class I; Molecular Sequence Data; HLA-A Antigens; Polymorphism, Genetic; Peptides; Ligands; HLA-A24 Antigen; Models, Molecular; Amino Acid Sequence