The impact of HIV on maternal morbidity in the Pre-HAART era in Uganda.

Journal article

OBJECTIVE: To compare maternal morbidity in HIV-infected and uninfected pregnant women. METHODS: Major maternal morbidity (severe febrile illness, illnesses requiring hospital admissions, surgical revisions, or illnesses resulting in death) was measured prospectively in a cohort of HIV-infected and uninfected women followed from 36 weeks of pregnancy to 6 weeks after delivery. Odds ratios of major morbidity and associated factors were examined using logistic regression. RESULTS: Major morbidity was observed in 46/129 (36%) and 104/390 (27%) of the HIV-infected and HIV-uninfected women, respectively, who remained in followup. In the multivariable analysis, major morbidity was independently associated with HIV infection, adjusted odds ratio (AOR) 1.7 (1.1 to 2.7), nulliparity (AOR 2.0 (1.3 to 3.0)), and lack of, or minimal, formal education (AOR 2.1 (1.1 to 3.8)). CONCLUSIONS: HIV was associated with a 70% increase in the odds of major maternal morbidity in these Ugandan mothers.

Authors: Nuwagaba-Biribonwoha, H; Mayon-White, R; Okong, P; Brocklehurst, P; Carpenter, L

• Journal: Journal of pregnancy
• Volume: 2012
• Pages: 508657
• Publication date: 2012-01-01
• DOI: 10.1155/2012/508657
• EISSN: 2090-2735
• ISSN: 2090-2727
• Language: English
• Keywords: Follow-Up Studies; HIV Infections; Morbidity; Adult; Pregnancy Complications; Odds Ratio; Surgical Procedures, Operative; Maternal Mortality; Case-Control Studies; Multivariate Analysis; Pregnancy Complications, Infectious; Pregnancy; Humans; Prospective Studies; Hospitalization; Fever; Female; Uganda; Logistic Models; Risk Factors