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Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.

Abstract:

BACKGROUND: Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-term monoclonal antibody treatment. METHODS: We depleted 95% of circulating lymphocytes in 27 patients with multiple sclerosis by means of a 5-day pulse of the humanised anti-CD52 monoclonal antibody, Campath-1H. Clinical and haematological consequences of T-cell depletion, and in-vitro responses of patients'...

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Publication status:
Published

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Authors


Coraddu, F More by this author
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Journal:
Lancet
Volume:
354
Issue:
9191
Pages:
1691-1695
Publication date:
1999-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:3fd3f5be-ec50-4581-ab8f-3bcd764b734b
Source identifiers:
12454
Local pid:
pubs:12454

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