- Abstract:
-
BACKGROUND: Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-term monoclonal antibody treatment. METHODS: We depleted 95% of circulating lymphocytes in 27 patients with multiple sclerosis by means of a 5-day pulse of the humanised anti-CD52 monoclonal antibody, Campath-1H. Clinical and haematological consequences of T-cell depletion, and in-vitro responses of patients'...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(99)02429-0
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- Journal:
- Lancet
- Volume:
- 354
- Issue:
- 9191
- Pages:
- 1691-1695
- Publication date:
- 1999-11-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:3fd3f5be-ec50-4581-ab8f-3bcd764b734b
- Source identifiers:
-
12454
- Local pid:
- pubs:12454
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.
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