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GTP cyclohydrolase II structure and mechanism.

Abstract:

GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The essential role of riboflavin in metabolism and the absence of GTP cyclohydrolase II in higher eukaryotes makes it a potential novel selective antimicrobial drug target. GTP cyclohydrolase II catalyzes a distinctive overall reaction from GTP cyclohydrolase I; the latter converts GTP to dihydroneopterin triphosphate, utilized...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m507725200

Authors


Lockyer, M More by this author
Hawkins, AR More by this author
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Journal:
The Journal of biological chemistry
Volume:
280
Issue:
44
Pages:
36912-36919
Publication date:
2005-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:3fc79a5b-cddf-419f-80c7-c4e8953aa8e2
Source identifiers:
72627
Local pid:
pubs:72627

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