- Abstract:
-
GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The essential role of riboflavin in metabolism and the absence of GTP cyclohydrolase II in higher eukaryotes makes it a potential novel selective antimicrobial drug target. GTP cyclohydrolase II catalyzes a distinctive overall reaction from GTP cyclohydrolase I; the latter converts GTP to dihydroneopterin triphosphate, utilized...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m507725200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 280
- Issue:
- 44
- Pages:
- 36912-36919
- Publication date:
- 2005-11-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:3fc79a5b-cddf-419f-80c7-c4e8953aa8e2
- Source identifiers:
-
72627
- Local pid:
- pubs:72627
- Copyright date:
- 2005
Journal article
GTP cyclohydrolase II structure and mechanism.
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