Journal article icon

Journal article

An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

Abstract:

The common view is that T lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily naïve and central memory cells) elongated telomeres by acquiring telomere vesicles from antigen-presenting cells (APCs) independently of telomerase action. Upon contact with these T cells, APCs degraded shelterin to donate telomeres, which were cleaved by the telomere trimming factor TZAP, and then transferred in extracellular vesicles at the immunological synapse. Telomere...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41556-022-00991-z

Authors


More from this funder
Name:
European Commission
Grant:
670930
Publisher:
Springer Nature
Journal:
Nature Cell Biology More from this journal
Volume:
24
Pages:
1461-1474
Publication date:
2022-09-15
Acceptance date:
2022-08-11
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Language:
English
Keywords:
Pubs id:
1279242
Local pid:
pubs:1279242
Deposit date:
2022-09-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP