Non-invasive assessment of skeletal muscle fibrosis in mice using nuclear magnetic resonance imaging and ultrasound shear wave elastography

Journal article

Dupuytren disease is a benign, progressive fibroproliferative disorder of the hands. To date, only one pharmacotherapy (clostridial collagenase) has been approved for use in Dupuytren disease. There is a great need for additional nonsurgical methods that can be used to either avoid the risks of invasive treatments or help minimize recurrence rates following treatment. A number of nonsurgical modalities have been discussed in the past and continue to appear in discussions among hand surgeons, despite highly variable and often poor or no long-term clinical data. This article reviews many of the pharmacotherapies discussed in the treatment of Dupuytren disease and novel therapies used in inflammation and fibrosis that offer potential treatment options

Authors: Martins-Bach, AB; Bachasson, D; Araujo, ECA; Soustelle, L; Loureiro de Sousa, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Scientific Reports
• Volume: 11
• Issue: 1
• Pages: 284-284
• Article number: 284
• Publication date: 2021-01-11
• DOI: 10.1038/s41598-020-78747-8
• EISSN: 2045-2322
• ISSN: 2045-2322
• Language: English
• Keywords: Materials science; Medicine; Infiltration (HVAC); Radiology; Internal medicine; In vivo; Ultrasound; Inflammation; Muscle disorder; Pathology; Elastography; Pathological; Magnetic resonance elastography; Anatomy; Fibrosis; Stiffness; Muscle stiffness; Biology; Magnetic resonance imaging; Skeletal muscle