The search for new antigenic targets in myasthenia gravis.

Journal article

Around 80% of myasthenia gravis patients have antibodies against the acetylcholine receptor, and 0-60% of the remaining patients have antibodies against the muscle-specific tyrosine kinase, MuSK. Another recently identified antigen is low-density lipoprotein receptor-related protein 4 (Lrp4). To improve the existing assays and widen the search for new antigenic targets, we have employed cell-based assays in which candidate target proteins are expressed on the cell surface of transfected cells...

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Authors: Cossins, J; Belaya, K; Zoltowska, K; Koneczny, I; Maxwell, S

• Publication status: Published
• Journal: Annals of the New York Academy of Sciences
• Volume: 1275
• Issue: 1
• Pages: 123-128
• Publication date: 2012-12-01
• DOI: 10.1111/j.1749-6632.2012.06833.x
• EISSN: 1749-6632
• ISSN: 0077-8923
• Language: English
• Keywords: Receptors, Cholinergic; Autoantigens; Myasthenia Gravis; Cell Line; Receptor Protein-Tyrosine Kinases; LDL-Receptor Related Proteins; Humans; Autoantibodies