IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

Journal article

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but ...

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Authors: Gyrd-Hansen, M; Meier, P

• Journal: Nature reviews. Cancer
• Volume: 10
• Issue: 8
• Pages: 561-574
• Publication date: 2010-08-01
• DOI: 10.1038/nrc2889
• EISSN: 1474-1768
• ISSN: 1474-175X
• Language: English
• Keywords: Toll-Like Receptors; Inhibitor of Apoptosis Proteins; Caspase Inhibitors; NF-kappa B; Humans; Caspases; Neoplasms; Ubiquitin; Apoptosis; Neoplasm Metastasis; Signal Transduction; Animals; Lymphoma, B-Cell, Marginal Zone; Inflammation