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Fasting plasma insulin concentrations are associated with changes in hepatic fatty acid synthesis and partitioning prior to changes in liver fat content in healthy adults

Abstract:

Resistance to the action of insulin impacts on fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver and triglyceride export from the liver. To understand the metabolic consequences of hepatic fatty acid synthesis, partitioning, oxidation and net liver fat content in the fasted and postprandial states we studied healthy men and women with varying degrees of insulin resistance before and after consumption of a mixed meal using stable-isotope tracer methodologies...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.2337/db16-0236

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Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Author
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Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
65
Issue:
7
Pages:
1858-1867
Publication date:
2016-07-05
Acceptance date:
2016-04-14
DOI:
EISSN:
1939-327X
ISSN:
1099-0895
Pubs id:
pubs:616163
URN:
uri:3f93d1ae-6537-4cb9-a0c4-fe2d1335a9b8
UUID:
uuid:3f93d1ae-6537-4cb9-a0c4-fe2d1335a9b8
Local pid:
info:fedora/pubs:616163

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