Journal article
Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges
- Abstract:
- The Kaplan-Meier (K-M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one cause of failure. In reality, failures are captured at pre-scheduled time points and patients can fail treatment due to a variety of causes other than the primary endpoint, commonly termed competing risk events. Ignoring these underlying assumptions can potentially distort the derived efficacy estimates and result in misleading conclusions. This review details the evolution of statistical methods used to derive anti-malarial efficacy for uncomplicated Plasmodium falciparum malaria and assesses the limitations of the current practices. Alternative approaches are explored and their implementation is discussed using example data from a large multi-site study.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.7MB, Terms of use)
-
- Publisher copy:
- 10.1186/s12936-017-2074-7
Authors
- Publisher:
- BioMed Central
- Journal:
- Malaria journal More from this journal
- Volume:
- 16
- Issue:
- 1
- Pages:
- 430
- Publication date:
- 2017-10-26
- Acceptance date:
- 2017-10-19
- DOI:
- ISSN:
-
1475-2875
- Pmid:
-
29073901
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:742523
- UUID:
-
uuid:3f8e9e9d-ae13-435c-99db-ced87d438dcf
- Local pid:
-
pubs:742523
- Source identifiers:
-
742523
- Deposit date:
-
2017-11-04
Terms of use
- Copyright holder:
- Dahal et al
- Copyright date:
- 2017
- Notes:
-
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/
publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record